When comparing the combined data (iTRAQ LC MS/MS and STK chip array) obtained from grade II and III meningiomas to the kinomic profiling of the sh33-AKAP12, the benign cell line acquired a similar signature to grade III meningiomas, suggesting AKAP12 a role in meningioma progression from grade I to higher grades. Here, AKAP12 is linked to meningioma.