To determine how AKAP12 and meningioma grade influence global signaling we employed Ingenuity Pathway Analysis (IPA) of STK peptide array (sh33-AKAP12: sh33NS) and the grade II:I and III:I phosphoproteome/kinome combined datasets (iTRAQ LC MS/MS and STK peptide array). This evidence concerns the gene AKAP12 and meningioma.