After clustering kinases by groups, we found that AKAP12 knockdown resulted in regulation of four major groups: AGC (39.9%) CAMK (16.8%), STE (16.8%), and CMGC (11.6%) which are the most affected groups in high-grade meningiomas (grade II: AGC 70.8%, CMGC 28.8%, CAMK 23.44%, and STE 20.3%; grade III: CMGC 73.6%, AGC 32.1%, and CAMK 25.0%) (Fig. 4b), strengthen the involvement of the AKAP12 in meningioma malignancy. This evidence concerns the gene SULT1E1 and meningioma.