Hence, tandospirone might act as a partial agonist on 5-HT1A autoreceptors and a full agonist on 5-HT1A heteroreceptors, to compensate for altered 5-HT1A receptor signaling in the dorsal raphe and the hippocampus, reduce anxiety-like behavior and correct the neurogenic deficits, respectively. Here, HTR1A is linked to Anxiety.