Since selective serotonin reuptake inhibitor (SSRI) antidepressants elevate 5-HT availability and promote hippocampal neurogenesis, which is required for antidepressant effects11, a positive relationship between 5-HT signaling and hippocampal neurogenesis has been established, with the role of the 5-HT1A receptor becoming well elucidated in both anxiety/depression12,13 and neurogenesis14. Here, HTR1A is linked to Anxiety.