Since similar alterations in hippocampal neurogenesis have been observed following chronic binge-like alcohol administration by gastric gavage in rats, with these changes associated with concomitant cognitive impairments65, further work is required to determine whether neurogenic deficits following long-term DID lead to cognitive deficits and whether these deficits are mediated by a 5-HT1A receptor-dependent mechanism. Here, HTR1A is linked to Cognitive impairment.