To evaluate the contribution of 5-HT1A receptors in anxiety-like behavior following withdrawal from long-term binge-like drinking, we investigated the effects of the 5-HT1A partial agonist tandospirone (3 mg/kg) on mice experiencing a 24-h withdrawal from alcohol in a battery of behavioral tests (marble burying, elevated-plus-maze and open-field) (Fig. 1A). The gene discussed is HTR1A; the disease is Anxiety.