This trajectory of hippocampal atrophy was suggestive of being different to APOE ε4-ve/KIBRA non-T carriers (−0.006 cm3/year), however this did not reach significance (p = 0.125), even though this trajectory showed negligible difference to APOE ε4-ve/KIBRA T carriers. This evidence concerns the gene APOE and hippocampal atrophy.