When evaluating the effect of KIBRA on hippocampal atrophy in all cases, and co-varying for APOE ε4 carrier and Aβ-amyloid status, no significant difference (p = 0.242) was observed between T carriers (−0.017 cm3/year), and non-T carriers (−0.026 cm3/year) over six years (Supplementary Figure 1, Supplementary Table 1). Here, WWC1 is linked to hippocampal atrophy.