APOE and systemic lupus erythematosus: Such immunomodulatory properties dictate that ES-62 has protective effects in a number of mouse models of inflammatory disease, in particular collagen-induced arthritis (CIA)3–6, ovalbumin-induced airway-hyper-responsiveness (OAH)7–9, oxazolone-induced skin hypersensitivity (OSH)7, the MRL/Lpr model of systemic lupus erythematosus (SLE)10 and the Gld.ApoE−/− model of accelerated atherosclerosis in SLE11.