The data showed that low miR-539 expression was positively associated with lymph node metastasis (Table 1, P < 0.05) but no significant associations were observed with other parameters, including the age, primary tumor size, histological subtype, AJCC stage, histological grade, distant metastasis, and estrogen receptor. Here, ESR1 is linked to metastatic malignant neoplasm in the lymph nodes.