Intriguingly, hyperactivity of mTORC1 in liver cells has been shown to protect against steatosis in mice51; deletion of Tsc1 in mouse liver cells, which codes hamartin (TSC1) of the tuberous sclerosis complex (TSC) and controls the activity of mTORC154, specifically protected cells from high-fat diet induced, Akt-mediated steatosis through restriction of S6K1 independent of Akt suppression51. The gene discussed is RPS6KB1; the disease is steatosis.