FN1 and posterior cortical atrophy: Using a transcriptomic approach coupled with proteomic analysis of a unique patient-derived explant model, we provide evidence for a novel effect of AUY922-mediated inhibition of Hsp90 function leading to altered cytoskeletal organization that is associated with changes in fibronectin expression, intracellular delivery and secretion, and is consistent with an impact on PCa cell migration and metastatic potential.