Importantly, not only can extracellular vesicles promote motility and migration of tumor cells42, their cargo of extracellular matrix components, and specifically fibronectin located on the outer surface of these vesicles, have been implicated as a key mediator of directional invasive capacity, potentially due to stabilization of tumor cell protrusions into the stroma and tumor microenvironment43, and/or inter-cellular cross-talk44. The gene discussed is FN1; the disease is neoplasm.