However, despite the marked induction of FN1 expression in AUY922 treated PCa cells, ELISA assays performed to detect FN1 in the culture medium demonstrated that AUY922 (25 nM) caused a consistent and significant reduction in FN1 secretion by LNCaP cells compared to vehicle treated cells (Fig. 4A; n = 4 independent experiments). The gene discussed is FN1; the disease is posterior cortical atrophy.