The Manhattan plot of the corresponding meta-analysis is shown in Fig. 2, with top results listed in Table 2.The top SNP rs111940429, which is genome wide significant (P = 1.2E–08), is in an intergenic region of chromosome 2q12.3, with the closest gene PPP1R2P5; the C allele is less common in BD patients with BE (Mayo 0.93, GAIN 0.93) than in controls (Mayo 0.96, GAIN 0.97). The gene discussed is PPP1R2P5; the disease is Barrett esophagus.