PPP1R2 and Barrett esophagus: In the meta-analysis of BD cases with BE compared to controls, we identified a genome-wide significant variant in an intergenic region of chromosome 2q12.3, with the nearest gene encoding protein phosphatase 1 regulatory subunit 2 (PPP1R2), an inhibitor of the serine/threonine protein phosphatase 1 (PPP1) that binds to the active site of its catalytic subunit.