PRR5 and Barrett esophagus: The meta-analysis of BE in BD cases provided genome-wide significant evidence for association of BE with a group of SNPs in the PRR5-ARHGAP8 gene, where the more common allele is associated with reduced risk of BE behavior among BD patients (top SNPs rs726170 and rs8139558, OR = 0.52, p = 3.05E-08); the C allele at rs726170 is less common in BD patients with BE (Mayo 0.84, GAIN 0.81) as compared to those without BE (Mayo 0.89, GAIN 0.90).