ARHGAP8 and obesity due to melanocortin 4 receptor deficiency: We demonstrated that BE among BD patients is associated with variants of the PRR5-ARHGAP8 gene, a read-through transcript of neighboring genes PRR5 and ARHGAP8. PRR5 is a circadian clock gene that encodes a subunit of the mammalian target of rapamycin complex 2 (mTORC2) critical for neuronal survival, proliferation, and differentiation33, as well as energy balance, obesity, and hyperphagia34.