SOX2 and Barrett esophagus: Although no prior GWAS of BE have been performed, a GWAS of anorexia nervosa identified a variant in SOX2-OT;59 another variant in this region, rs4854912, was later confirmed in a GWAS of bipolar patients with either anorexia nervosa or bulimia nervosa compared to healthy controls, in an analysis that included GAIN data60.