The meta-analysis of BE in BD cases provided genome-wide significant evidence for association of BE with a group of SNPs in the PRR5-ARHGAP8 gene, where the more common allele is associated with reduced risk of BE behavior among BD patients (top SNPs rs726170 and rs8139558, OR = 0.52, p = 3.05E-08); the C allele at rs726170 is less common in BD patients with BE (Mayo 0.84, GAIN 0.81) as compared to those without BE (Mayo 0.89, GAIN 0.90). Here, ARHGAP8 is linked to Barrett esophagus.