SRF and cancer: As a member of the myocardin related transcription factor (MRTF) family, megakaryoblastic leukemia 1 (MKL1) is broadly expressed in many tissues [33] and functions as a co-activator of serum response factor (SRF), which played an important roles in the control of motile or contractile cell functions, especially during cancer metastasis, vascular smooth muscle cell and cardiac myocyte differentiation [33, 34].