The second predicted all-cause mortality among older women living with HIV/AIDS who also have substance and alcohol abuse problems based on sociodemographic factors (age and race), medical history factors (including using various drugs, alcohol and tobacco, having hepatitis C, prior antiretroviral therapy, CD4 counts, and viral load), and mental health factors (including a history of depression, anxiety, or psychosis) [48]. The gene discussed is CD4; the disease is hepatitis C virus infection.