In addition, we found that HMGA2 expression was significantly associated with tumour grade and myometrial invasion in patients with endometrial cancer and that HMGA2 expression levels were significantly up-regulated in the tissues of endometrial cancer patients with lymph node metastasis compared with those of patients without lymph node metastasis. Here, HMGA2 is linked to metastatic malignant neoplasm in the lymph nodes.