For example, thus far, genetic mutations were found in Mfn2 and reported to be associated with Charcot-Marie-Tooth (CMT) disease, the most common inherited neurological disorders, accounting for up to 20 to 30% of all axonal CMT type 2 cases, to a lesser degree, also be associated with optic atrophy, clinical signs of first motor neuron involvement, and early onset stroke [6–8]. The gene discussed is MFN2; the disease is nervous system disorder.