The 5XFAD mice overexpress mutant human APP(695) with the Swedish (K670 N, M671 L), Florida (I716V), and London (V717I) Familial Alzheimer’s Disease (FAD) mutations along with human PS1 harboring two FAD mutations, M146 L and L286 V. This evidence concerns the gene PSEN1 and early-onset autosomal dominant Alzheimer disease.