The overexpression of TGF-β has been implicated in fibrotic diseases of the kidney, liver, lung, skin, and other organs, and trapping TGF-β by increasing the expression of LAP in organ-specific cells leads to the suppression of fibrosis in the skin, hepatic tissue, and renal tissue [29, 33, 34]. This evidence concerns the gene TGFB1 and urogenital neoplasm.