The role of TILs, T effector (CD8+, CD4+) and T regulatory (FOXP3+, CTLA-4+, PD-1+) cells and CD56+ NK cells in ALNs is even less well studied and their contribution to the induction of immune-mediated tumour cell death in ALN metastases poorly documented. The gene discussed is CTLA4; the disease is neoplasm.