PLA2G7 and stroke disorder: Moreover, Stafforini et al demonstrated that loss-of-function mutations in the PLA2G7 gene are common in East-Asian populations, which could effectively abolish Lp-PLA2 activity and/or largely reduce the activity levels in heterozygotes.[34] Subgroup analysis indicated that Lp-PLA2 activity levels in patients with TIA were associated with a higher risk of recurrent vascular events compared with patients with stroke.