Clinical data suggested that the elevated levels of Lp-PLA2 mass and the higher levels of the corresponding activity were associated with the progression of atherosclerotic disease.[41] Certain human- and animal-based studies further highlighted an increase in the expression of Lp-PLA2 in atherosclerotic lesions and plasma, which were related to accelerated atherogenesis.[35,42,43] Although the most common cause of ischemic stroke is atherosclerosis, the causes of ischemic stroke are more heterogeneous compared with those noted in atherosclerotic heart disease. This evidence concerns the gene PLA2G7 and ischemic stroke.