The serum concentrations of inflammatory biomarkers such as C-reactive protein and IL-6 and red cell distribution width in the preablation phase have been indicated in AF occurrence and recurrence.[8–9] The underlying mechanisms were all related to oxidative stress and chronic inflammation in atrial myocardium, demonstrating that an increase in the concentration of biomarkers may aggravate atrial remodeling.[9] Atrial remodeling is a major characteristic of AF, which provides an inhomogeneous environment for electrical propagation and triggers ectopic or re-entrant activity. Here, IL6 is linked to atrial fibrillation.