Chromosomal translocations are regarded as an important prognostic indicator and are always associated with shorter survival in B-CLL patients.[8] Recently, several alternate translocations, such as t(4;14)(p16;q32) to generate FGFR3/IGH, t(11;14)(q13;q32) to form CCND1/IGH, t(14;18)(q32;q21) to produce IGH/BCL2 fusion, and t(18;22)(q21;q11) have been identified and provided further insights into the pathogenesis of CLL.[12–15] However, complex variant translocations may occur in CLL but have been rarely reported. Here, FGFR3 is linked to B-cell chronic lymphocytic leukemia.