Translocations involving IGH not only promote pathogenesis but also predict a poor prognosis of B-cell malignancies such as t(8;14)(q24;q32)(MYC/IGH) in Burkitt lymphoma (BL); t(11;14)(q13;q32) (CCND1/IGH) in mantle cell lymphoma (MCL); and t(14;18)(q32;q21) (IGH/BCL2) in follicular lymphoma (FL).[8] The cases with concomitant t(2;14) and t(14;19) translocations have previously been reported,[16] and they are always regarded as a rare recurrent chromosomal changes associated with atypical cytology, trisomy 12, and a progressive disease in CLL.[13,17,18]. The gene discussed is CCND1; the disease is mantle cell lymphoma.