The present study is the first report of a CLL case with a complex variant translocation involving 3 chromosomes 2, 11, 14 named t(2;14;11)(p16.1;q32;q23)/BCL11A;IGH;MLL, especially concurrent with t(14;19)(q32;q13.3)/IGH;BCL3. In contrast to MYC/IGH, CCND1/IGH and IGH/BCL2, the roles for IGH;BCL3 and BCL11A;IGH;MLL fusions in CLL remain poorly understood; however, it is possible the target genes that become overexpressed or gained new functions may be relevant to the poor prognosis of CLL. This evidence concerns the gene BCL3 and B-cell chronic lymphocytic leukemia.