EDN1 and hydrops fetalis: Among them, 15 studies provided relevant data about ET-1 with 6151 participants,[3,5,10,14,26–36] 9 studies for big ET-1 with 7928 participants,[11,37–44] and 6 studies for CT-proET-1 with 4078 participants,[45–50] 1 study included both ET-1 and big ET-1 with 206 participants,[51] and 1 study included both ET-1 and CT-proET-1 with 134 participants.[12] Diagnosis of HF was conducted according to symptom, echocardiography or New York Heart Association (NYHA) classes.