Plasma ET-1 concentration is correlate with clinical and hemodynamic severity under pathological conditions.[55] Big ET-1 is mainly cleared in liver and kidney, as a consequence, plasma level of big ET-1 can be influenced by hepatic or renal dysfunction.[53] Plasma CT-proET-1 level is correlated with renal function, age, left atrial size, and diastolic blood pressure.[56] Whether an adjustment of these factors should be made in the determination of the prognostic value of ET-1-related peptides still needs further exploration. Here, EDN1 is linked to Abnormal renal physiology.