Angiogenesis is essential for tumor growth and metastasis, whereas the vascular endothelial growth factor (VEGF) and its receptors (VEGFRs) play a crucial role in angiogenesis.[9] VEGF family includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, and the placental growth factor (PIGF). The gene discussed is VEGFA; the disease is neoplasm.