Therefore, combining the long history of HBV with the clinical manifestations of weakness and dizziness, we presumed that the nonmalignant serum AFP elevation was caused by the acute exacerbation of chronic hepatitis B. Recently, this conjecture was supported by strong evidence: the latest level of AFP was down to 22.0 ng/mL, close to normal. The gene discussed is AFP; the disease is chronic hepatitis B virus infection.