APOE and brain infarction: In other studies, however, the ApoE genotype has been shown to have no association with cerebral infarction.[36] One study showed that the presence of the ApoE∗E4 genotype does not have a major influence on functional recovery after IS.[37] Another recent study suggested that the ApoE∗E4 genotype increases the risk of cerebral infarction in the Chinese population.[38] The possibility that the E4 allele of ApoE could act as a risk factor in IS is still controversial and remains a matter of ongoing study.[36]