APOB and hyperlipoproteinemia type 3: ApoE∗E2 increases triglyceride (TG)and cholesterol levels, resulting in type III hyperlipoproteinemia.[5]ApoE∗E4 increases cholesterol, low-density lipoprotein (LDL), and apolipoprotein B (ApoB) levels, resulting in atherosclerosis, hyperlipidemia, and cardiovascular disease.[5] The accumulation and over expression of ApoE can stimulate very-low-density lipoprotein (VLDL) and TG production, impair VLDL lipolysis, and cause hypertriglyceridemia.