In chronic lymphocytic leukaemia (CLL), whole genome sequencing (WGS) of 150 tumour/normal pairs alongside with DNase-seq and chromatin immunoprecipitation sequencing (ChIP-seq) identified recurrent mutations in the 3′ UTR region of NOTCH1 gene and in the active enhancer of PAX5 (9). Here, NOTCH1 is linked to B-cell chronic lymphocytic leukemia.