Furthermore, similar to wild-type MH-S cells, infection of acat-1-/- cells with wild-type C. burnetii showed increased LD numbers compared to mock-infected and dotA mutant-infected cells (S2A Fig) with an average of more than 75 LDs/cell at 1, 2 and 4 days after C. burnetii infection. The gene discussed is ACAT1; the disease is infection.