Dose-response evidence has shown that regular physical activity can reduce the onset of colorectal cancer by 20–25% in both men and women.5 Mechanisms by which physical activity reduces the risk of colorectal cancer, were not entirely clear, albeit assumptions such as changes in the material in gastrointestinal transmit time, changes in immune function as well as changes in prostaglandin levels, insulin, insulin-like growth factors, bile acid secretion, serum cholesterol and pancreatic and gastrointestinal hormone profiles have been forwarded [4–6]. This evidence concerns the gene INS and colorectal cancer.