VEGFA and obesity due to melanocortin 4 receptor deficiency: When we investigated the impact of both obesity and Tx treatment, Leptin and VEGF expressions were decreased in MCF-7 cells co-cultured with MA30 and Tx (R = 0.44, p<0.05; R = 0.51, p = 0.05, vs co-cultured with MA20 and Tx).