The transcription factors Sp1, Sp3 and Sp4 are overexpressed in pancreatic cancer cells and like MALAT-1, knockdown of Sp1, Sp3 and Sp4 or Sp1/Sp3/Sp4 (combined) results in decreased cell growth, induces apoptosis, and decreases migration [42–45]. Here, SP1 is linked to familial pancreatic carcinoma.