Thus, the loss of MALAT-1 in the transgenic mice driven by Kras expression and p53 deletion (-/- or +/-) had only a minimal impact on this aggressive tumor model, whereas the loss of MALAT-1 in an orthotopic and xenograft mouse models of pancreatic cancer decreased tumor growth and invasion [9, 21]. This evidence concerns the gene TP53 and familial pancreatic carcinoma.