The expression and prognostic value of MALAT-1 has now been extensively investigated in multiple tumor types showing that high tumor expression of MALAT-1 is a negative prognostic factor for lung, liver, pancreatic, melanoma, cervical, colorectal, gastric, multiple myeloma, clear cell, renal cell, glioma and adrenocortical cancer patients [4–18]. The gene discussed is MALAT1; the disease is central nervous system cancer.