We also observed high expression of MALAT-1 in pancreatic cancer cells (S1A Fig); knockdown of MALAT-1 (siMALAT-1) in Panc1 and MiaPaCa2 cells decreased cell proliferation and induced G2/M arrest (Fig 1A and 1B) and induced apoptosis as indicated by increased Annexin V staining and expression of cleaved PARP (Fig 1C). This evidence concerns the gene MALAT1 and familial pancreatic carcinoma.