Although loss of MALAT-1 decreased pancreatic tumor growth and metastasis in a mouse orthotopic model [9, 15], the loss of MALAT-1 in highly aggressive p53L/L;LSL-KrasG12DL/+;p48Cre+/- and the p53L/+ heterozygotes only slightly increased survival time in the p53L/+ heterozygotes. The gene discussed is MALAT1; the disease is pancreatic neoplasm.