PIK3CA and granulosa cell tumor: Recently, Wang and coworkers have reported the wide genome sequencing of 10 cases of granulosa cell tumors and observed in 100% of these patients the pathognomic FOXL2 mutation; only few additional mutations were observed in these tumors: TP53 mutation in 20% of cases and PIK3CA, CTNNB1 and PIK3R1 in 10% of cases [27].