It was shown that NOTCH3 plays a key role in the control of ovarian cancer stem cells: in fact, NOTCH overexpression in ovarian cancer cells determines an expansion of cancer stem cells, while NOTCH signaling inhibitors (gamma-secretase inhibitors) decrease the number of cancer stem cells; interestingly, the combination of gamma secretase inhibitors (NOTCH inhibitors) and platinum exerts a complete inhibitory effect on cancer stem cells [251]. The gene discussed is NOTCH3; the disease is ovarian cancer.