CD117+/CD44+ cells isolated from the ascitic fluid of ovarian cancer patients are very sensitive to the anti-cancer stem cell antibiotic salinomycin: this drug added alone induced an inhibition of stemness markers of CD117+/CD44+ cells, such as SOX2 and OCT 3-4 and added together with paclitaxel induced apoptosis of these cells [244]. This evidence concerns the gene SOX2 and cancer.