In addition to mutations in cancer genes identified in uterine and ovarian carcinomas, such as TP53, PI3KCA, PPP2R1A, KRAS, PTEN, CHD4 and BCOR, recurrent mutations in genes encoding histone H2A and H2B, as well as significant amplification of the segment of chromosome 6p harboring the histone gene cluster containing these genes [100]. This evidence concerns the gene PTEN and ovarian carcinoma.