CD44 and neoplasm: Thus, Latifi and coworkers have shown that cisplatin induces an epithelial to mesenchymal transition in ovarian cancer cells derived from advanced stage patients: tumor cells surviving to cisplatin treatment in vitro changed their morphology from a typical epithelial to a typical mesenchymal pattern, reduced E-cadherin and increased N-cadherin and vimentin expression; in parallel, it was observed an increased expression of stem cell-associated membrane markers such as CD133, CD44, CD117, EpCAM and of the stem cell factors Nanog and Oct-4 [248].