TP53 and cancer: This important study provided evidence that this type of cancer is characterized by TP53 mutations in almost all tumors (96%); few additional genes are recurrently mutated in HGS-OvCas, but at a much lower frequency than TP53: BRCA1 about 12.5% (9% of germline mutation and 3.5% somatic mutations), BRCA2 about 11.5% (8% germline mutations and 3.3% somatic mutations), CSMD3 6%, NF1 4%, CDK12 3%, GABRA6 2% and RB1 2% (Figure 1) [6].