SMARCA4 and neoplasm: Recently, a comprehensive genomic profiling of SCCOHT tumors was performed, showing that all cases displaying a classic morphology have a low tumor mutation burden (<6 mutations/Mb) and in 94% of cases display SMARCA4 mutations; in contrast, rare cases associated with large cell morphology are hypermutated (360 mutations/Mb) and are wild-type for SMARCA4 [171].