RSPO1 and ovarian carcinoma: As above indicated, only a part of the familial aggregation of Epithelial Ovarian Cancer can be explained by high-penetrance alleles of BRCA1 and BRCA2. Thus, additional susceptibility loci for Epithelial Ovarian Cancer: variant at 1p36 (nearest gene, WNT4), 4q26 (SYNPO2), 9q34.2 (ATAD5), 1p34.3 (RSPO1) and 6q22.1 (GPX6) [62].