CD44+MyD88+ epithelial ovarian stem cells grow as adherent cells, but when grown at high cell density are able to generate some spheroids, containing epithelial ovarian cancer cells that have undergone an epithelial-mesenchymal transition (as evidenced by the acquisition of mesenchymal markers and of TWIST-1, SLUG and VIMENTIN, mesenchymal markers associated with the process of EMT); the spheroid mesenchymal cells are able to revert to an epithelial phenotype when switched into appropriate cell culture conditions (i.e., they undergo MET) [231]. Here, TWIST1 is linked to ovarian carcinoma.