On the basis of the identification of KLF10 (Kruppel Like Factor 10), involved in PTEN–AKT signaling activation, as a direct downstream target of miR-410 in MM, it was further demonstrated the contribution of OIP5-AS1 in the KLF10–PTEN–AKT signaling pathway in MM cells, very likely through a negative regulation of miR-410. This evidence concerns the gene OIP5 and Miyoshi myopathy.