It’s noteworthy how, even with carcinoembryonic antigen (CEA) values within normal range, serum ANGPTL2 could still discriminate CRC patients from healthy controls (AUC values over 0.8, some of the highest AUC levels for serum biomarkers compared with CEA 0.68 and CA 19.9 0.65 [102]. This evidence concerns the gene ANGPTL2 and colorectal carcinoma.