A Japanese group recently investigated clinical relevance of ANGPTL4 in HCC testing ANGPTL4 mRNA levels in tumor and non-tumor liver tissues of HCC patients and their correlation to clinical features The results showed that lower expression level of ANGPTL4 mRNA in cancer tissues of HCC patients was associated with advanced TNM stage, poor differentiation, higher AFP levels, worse DFS after hepatectomy and OS of patients. The gene discussed is AFP; the disease is hepatocellular carcinoma.