It’s noteworthy how, even with carcinoembryonic antigen (CEA) values within normal range, serum ANGPTL2 could still discriminate CRC patients from healthy controls (AUC values over 0.8, some of the highest AUC levels for serum biomarkers compared with CEA 0.68 and CA 19.9 0.65 [102]. The gene discussed is CEACAM5; the disease is colorectal carcinoma.