CCL2 and obesity due to melanocortin 4 receptor deficiency: 2003; Gregor and Hotamisligil 2011) in the mWAT, but not in the eWAT, of obese rats, as described for CCL2, an important marker of macrophage infiltration, by Yu et al. (2006). While both adipose tissue depots have been linked to the risk of developing obesity‐related diseases (Bjørndal et al. 2011), the adipose depot‐specific cytokine response to cafeteria‐diet corroborates the assumption that insulin resistance and increased glycemia might be more associated to increased specific fat mass depots than to total body fat mass (Park et al. 2016).