Remarkably, the unilocular to multilocular pattern rate was higher (1.3:1, 1.5:1, respectively) in the tumors with BRAF and multiple gene mutations, in contrast to SMO, NRAS, HRAS, and EGFR-mutated ameloblastomas (1:3, 1:2, respectively). The gene discussed is BRAF; the disease is ameloblastoma.