CXCR4 and atherosclerosis: To examine the role of neutrophils in atherosclerosis, it was found that the administration of a CXCR4 antagonist to induce neutrophilia in Apolipoprotein E knockout (Apoe−/−) mice triggered the rapid development of atherosclerosis due to abnormal lipoprotein metabolism (Zernecke et al. 2008).