Conversely,PALB2 sequencing in non-BRCA1/2 familial breast cancer cases led to the identification of germline missense mutations in the coiled-coil domain (L35P), identified in patients with a truncating mutation in the second allele, and WD40 repeat domain (L939W and L1143P)22,23. Here, BRCA1 is linked to breast carcinoma.