Those who respond with little improvement, or even with adverse response, are often termed “nonresponders” or “exercise resistant.” With regard to prediabetes, individuals with IFG + IGT have attenuated insulin sensitivity responses to high-volume (300 min/wk)/high-intensity (85% HRmax) exercise with approximately 7% weight loss treatment as compared to IFG or IGT alone [6, 7]. The gene discussed is INS; the disease is prediabetes syndrome.