TNF and Sepsis: Six patients (of whom 2 had sepsis, 2 severe sepsis, and 2 septic shock) fulfilled the criteria for immunodepression according to locally established thresholds with critically decreased HLA-DR expression (<150 MFI) and ex vivo stimulated TNFα production (TNFα < 175 pg/mL; Millenium test, DPC Biermann, Bad Nauheim, Germany).