An overwhelming and sustained proinflammatory immune response resulting in excessive levels of highly potent proinflammatory cytokines such as tumour necrosis factor alpha (TNFα), interleukin-1 (IL-1), interleukin-6 (IL-6), and interleukin-8 (IL-8) can lead to rapid development of shock and multiple organ failure (MOF) [4]. This evidence concerns the gene CXCL8 and Multiple Organ Failure.