CD4 and neoplasm: Univariate analysis showed a significant association between the presence of high stromal TILS and the expression of PD-L1 on ≥25% of tumor cells (p = 0.008) and ≥10% of inflammatory cells (p = 0.002); this association was independent from the prevalent lymphocyte subset (CD8+ or CD4+), and from the CD8/ CD4 ratio.