Similar to bimodal NORED and NORED exclusive regions, MethylMosaic exclusive-associated genes were also enriched nasopharyngeal carcinoma (149 genes, q=1.07×10−19), TP53 targets (126 genes, q=3.13×10−26), Alzheimer's disease upregulated genes (205 genes, q=9.61×10−52), and metabolic syndrome (125 genes, q=1.31×10−24; Supplementary Table S8). Here, TP53 is linked to metabolic syndrome.