NORED exclusive-associated genes were also enriched nasopharyngeal carcinoma (163 genes, q=1.92×10−31), TP53 targets (113 genes, q=6.18×10−24), Alzheimer’s disease upregulated genes (146 genes; 1.98×10−26), and metabolic syndrome (99 genes, q=4.06×10−16; Supplementary Table S7). This evidence concerns the gene TP53 and early-onset autosomal dominant Alzheimer disease.