Notably, in a large cohort of 133 patients with B-cell malignancies who received anti-CD19 CAR-T cell (JCAR014) following lymphodepletion chemotherapy, the investigators showed that fever in patients with grade ≥ 4 CRS not only presented and peaked earlier after CAR-T cell infusion, but also reached a higher maximum temperature and was of longer duration than that of in patients with grade<4 CRS [13]. The gene discussed is CD19; the disease is congenital rubella syndrome.