The data from a study of 133 patients treated with JCAR014 have indicated that biomarkers of endothelial activation including von Willebrand Factor (VWF) and angiopoietin (Ang)-2 are elevated during severe CRS, which is consistent with the presentation of vascular instability, capillary leak, and consumptive coagulopathy in severe CRS [15]. Here, VWF is linked to congenital rubella syndrome.