The cytokine profiles involved in CRS following CAR-T cell therapy encompass not only the effector cytokines such as interferon (IFN)-γ, IL-2, soluble IL-2Rα, IL-6, soluble IL-6R and granulocyte-macrophage colony-stimulating factor (GM-CSF), but also the cytokines mainly secreted by the monocytes and/or macrophages such as IL-1,IL-6, IL-8,IL-10,IL-12, tumor necrosis factor (TNF)-α, IFN-α, monocyte chemotactic protein (MCP)-1, macrophage inflammatory protein (MIP) 1α etc. [36–41]. The gene discussed is CSF2; the disease is congenital rubella syndrome.