Univariate binary logistic regression analysis for lipid profile, the lipid ratios, adiponectin, TNF-α and the adiponectin/TNF-α ratio showed that the LDL-C/HDL-C ratio, the TC/HDL-C ratio, AIP and TNF-α were positive risk markers for GDM development while HDL-C, adiponectin and the adiponectin/TNF-α ratio might have protective effects. The gene discussed is TNF; the disease is gestational diabetes.