CRP and inflammatory bowel disease: Due to the common symptoms of IBD with irritable bowel syndrome (IBS) and functional gastrointestinal disorders, the high cost and invasiveness of diagnostic procedures such as endoscopy, barium enema, CT scan and biopsy, low sensitivity and specificity of serologic (CRP) and hematological (ESR) parameters related to the symptoms and signs of IBD, physicians use a combination of clinical signs and symptoms, laboratory indices, radiology, colonoscopy and histopathology to diagnose the disease, assess its severity and predict the outcome (2-5).