Consistently, CD8 T cells from APDS patients exhibit normal degranulation activity (induced by anti-CD3 stimulation) and TNF/IFNγ production (11) with reduced secretion of IL-2, weak proliferative responses, and enhanced restimulation-induced cell death (RICD) (10, 11, 14, 22). Here, IL2 is linked to activated PI3K-delta syndrome.