PIK3CD and activated PI3K-delta syndrome: Identification of the genetic and molecular etiology of APDS has also led to more specific treatments, such as the use of the mTORC1 inhibitor (rapamycin) (10, 11, 23, 24, 26, 28, 34, 40) and specific p110δ inhibitors, which are currently being evaluated for APDS treatment in clinical trials.