A recent study using a glioblastoma mouse model has identified ten signature genes whose expression in TAMs is regulated by CSF1R signaling, i.e., Adm1, Arg1, Cd163, Cdh1, F13a1, Hmox1, Il1r2, Mrc1, Serpinb2, and Stab1 (15). The gene discussed is IL1R2; the disease is glioblastoma.