Both IRF5 and STAT1 SLE GWAS genes directly interacted with IRF8 and with the other 4 “magenta” module-associated genes such as interferon induced with helicase C domain 1 (IFIH1), IFIT1, GBP1, OASL, OAS2, and EIF2AK2 (Figure 5). Here, IRF5 is linked to systemic lupus erythematosus.