Consistent with a previous study that examined possible related signaling pathways shared in the pathogenesis of several systemic autoimmune diseases (SAID) such as dermatomyositis, polymyositis, rheumatoid arthritis, and SLE, a subset of five viral-related differentially expressed genes (i.e., RSAD2, IFIT3, ISG15, STAT1, and EIF2AK) was detected in peripheral blood of SAID probands and their unaffected twins (50). This evidence concerns the gene ISG15 and systemic lupus erythematosus.