By cross-linking susceptibility genes derived from SLE GWAS with clusters of co-expressed genes in “magenta” module, we found IRF8 to directly interact with the largest number of interferon-induced genes present in the “magenta” module including IFIT1, GBP1, OAS2, OASL, and STAT1 (Figure 5). This evidence concerns the gene IRF8 and systemic lupus erythematosus.