DSG1 and pemphigus: Based on the clinical presentation and the specificity of the anti-desmoglein (Dsg) autoantibodies, pemphigus is classified into two main forms, pemphigus vulgaris (PV), with autoantibodies targeting Dsg3, and in some cases also Dsg1, and pemphigus foliaceus (PF), with autoantibodies targeting Dsg1 (1).