TNF and B-cell non-Hodgkin lymphoma: Furthermore, elevated IFN-γ and TNF production was similarly observed after culture with rituximab-coated 721.221 B-cell lymphoma cells in the presence of IL-12 + 18 (Figures S1F,H in Supplementary Material), implying that potentiation of cytokine production by pro-inflammatory signals is not restricted to NKG2C-mediated activation but also detectable upon engagement of other adaptive NK-cell activating receptors such as CD16.