However, both infected cells and a robust inflammatory milieu are present during viral infection (15–17), and it remains incompletely understood whether adaptive NKG2C+ NK cells have completely lost their ability to sense IL-12 and IL-18 (IL-12 + 18) and rely solely on recognition of cellular stimuli, or whether adaptive NKG2C+ NK cells are able to functionally respond to these inflammatory cues in the context of target-cell encounter. The gene discussed is KLRC2; the disease is viral infectious disease.