Adaptive NKG2C+ NK cells in HCMV-seropositive individuals display skewed and narrow expression patterns of otherwise stochastically distributed killer Ig-like receptors, which is suggestive of oligoclonal or clonal-like expansion upon HCMV infection and parallels the pathogen-specific responses of T cells (9, 10). The gene discussed is KLRC2; the disease is cytomegalovirus infection.