CD52 expression is particularly high on T-cell prolymphocytic leukemia (T-PLL), Sézary syndrome (SS), acute lymphoblastic leukemia (ALL), CLL, and acute myeloid leukemia (AML) (36–39), which is the reason why it was selected as therapeutic target despite not having a clear role in the pathogenesis of these conditions. Here, CD52 is linked to B-cell chronic lymphocytic leukemia.