CXCR4 and B-cell chronic lymphocytic leukemia: Additionally, this couple controls organogenesis and development in several tissues (228, 229), hence CXCR4 is not surprisingly overexpressed in more than 23 different human cancers and has been demonstrated to be particularly relevant in B-cell malignancies like B-ALL, CLL, or MM (230, 231), T-cell malignancies such as T-ALL (232), and myeloid malignancies like AML (233).