In addition, CCR4 has been implicated in the pathogenesis of inflammatory diseases and cancer, being overexpressed in several T-cell disorders including adult T-cell leukemia–lymphoma (ATL), peripheral T-cell lymphoma (PTCL), and cutaneous T-cell lymphoma (CTCL) (212–214). The gene discussed is CCR4; the disease is primary cutaneous T-cell non-Hodgkin lymphoma.