CD52 expression is particularly high on T-cell prolymphocytic leukemia (T-PLL), Sézary syndrome (SS), acute lymphoblastic leukemia (ALL), CLL, and acute myeloid leukemia (AML) (36–39), which is the reason why it was selected as therapeutic target despite not having a clear role in the pathogenesis of these conditions. This evidence concerns the gene CD52 and acute lymphoblastic leukemia.