One of the most associated spot for MI and CAD, identified by GWA strategies in cohorts of different ethnicities (58, 59), is a 58 Kb non-coding region on chromosome 9p21, localized close to the CDKN2A and CDKN2B genes, in the context of a known non-coding RNA locus (ANRIL). This evidence concerns the gene CDKN2A and coronary artery disorder.