Intriguingly, while the proximity to CDKN2A and CDKN2B, two genes with a role in cell cycle inhibition and tumor suppression, may explain a causal association with cancer, the 9p21 locus does not contain described genes for CAD, and is not linked with major cardiovascular risk factors, such as plasma lipoproteins, and hypertension. This evidence concerns the gene CDKN2A and coronary artery disorder.