IL6 and endothelial dysfunction: By transcriptome profiling of bone marrow-derived macrophages from db/db and diet-induced insulin-resistant type 2 diabetic mice, an increase in lncRNA E330013P06 has been observed, demonstrating that this lncRNA promoted foam cell formation and endothelial dysfunction through the expression of inflammatory genes like Nos2, IL6 and ptgs2 (189).