HMGCR and Hypercholesterolemia: Statins are structural analogs of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA), the substrate of HMG-CoA reductase, and have been used as potent cholesterol-lowering drugs for the treatment of hypercholesterolaemia and coronary heart disease (Stein, 2002; Rader, 2003).