N-methyl-D-aspartate ionotropic glutamate receptor (NMDA) is a ligand-gated ion channel that is crucial for excitatory neurotransmission and its excessive activation plays a key role in mediating some aspects of synaptic dysfunction in several neuronal disorders including PD (Lau and Tymianski, 2010). This evidence concerns the gene GLRA3 and Parkinson disease.