The levels of S100B may rise to high concentration (μM) under some conditions and because of this, the concentration of S100B has been proposed as biomarker for pathological conditions of the brain, including perinatal brain distress, acute brain injury, brain tumors, neuroinflammatory and neurodegenerative disorders, and psychiatric disorders (Michetti et al., 2012). The gene discussed is S100B; the disease is brain neoplasm.